Since SIRIUS 5, a user account and a license is required to use the webservice-based features of SIRIUS.

Non-webservice-based features include molecular formula annotation using fragmentation trees and isotope pattern analysis - this is performed on your local computer and no license is needed. Some molecular formula annotation strategies (like formula database search) may require a web service connection.

Webservice-based features are essentially advanced structure elucidation features including structure database search with CSI:FingerID, CANOPUS compound class prediction and MSNovelist.
No worries, these and upcoming features will stay free for academic/non-commercial use and provided/hosted by the FSU Jena. On the other hand the Bright Giant GmbH offers SIRIUS web service hostings for commercial users.

Academic users

Access to the academic license will be granted (automatically) based on the domain of your institutional email address. You need to use your institutional email address for your SIRIUS account to benefit from free academic licenses.

The FSU Jena maintains an allow-list of academic/non-profit intuitions/organizations. However, such a list will never be complete. If your Institution does not have access but you think it should, please email us with some information about your institution (e.g. official website). We will perform manual validation and grant access to your institution if it meets the requirements for the academic/non-commercial license.

Non-academic users

Please contact Bright Giant via email for offerings and pricing.

Account creation

User accounts can be created directly via the SIRIUS GUI. Open Webservice -> Account. Click on Create Account and enter you institutional (not private) email address and specify a password for your account. Verify your email address with the link that will be sent to your inbox. Finally, click on Log in and log in with your account credentials.

To login from the CLI use the following command:

sirius login -u <email> -p

See sirius login --help for details.

NOTE: When logging in, SIRIUS will retrieve a long-lived refresh_token that will be stored until it is invalidated by logging out. Your username and password will never be stored locally.